Welcome to the new software
package. The Enterprise Biology Software Project recently
transformed MRI volumes of living brains into mathematical markers,
which, in turn, were used to diagnose disorders objectively (Report, 2012). This year, we will ask, “Can we use the
postmortem data in the stereology database to diagnose disorders of
the living brain? At first, the answer is no. Postmortem data alone or in
combination with MRI (living) data, consistently missed the
Why? Volumes in living
brains change postmortem - some parts swell, others shrink.
Moreover, the same parts can change differently in control and
experimental settings. This nightmarish scenario compromises our
ability to generate absolute values and to detect changes reliably. When
the distorted volume references - expressed as the variables in hierarchy
equations - fail to cancel, access to the all important absolute
values becomes problematic. In effect, the approach becomes
If the postmortem data of
stereology can neither diagnose disorders with mathematical markers
nor detect changes with absolute data from hierarchy equations, then
our current research model - based on reductionism alone - becomes ineffective. The current report addresses this challenging
problem of postmortem stereology and offers practical solutions.
software package offers:
The Information Infrastructure.
digital library, including mathematical markers.
MRI database for the brain.
Correction factors for postmortem data.
Updated programs, documents, and databases.
Updated theory structure for biological complexity.