the new software package. The Enterprise Biology Software Project
recently discovered - entirely by chance - a remarkable literature
database that includes MRI volumes of the brain. Running these
volume data through our information infrastructure quickly produced
a new complex data type called the mathematical marker. It
consists of two concatenated triplets (AX:BY:CZ), one identifying parts
(A:B:C) and the
other proportions (X:Y:Z). In effect, this new MRI database
of markers serves to generalize a complex biomedical literature in
terms of local and global patterns. Starting with more than
700,000 mathematical markers characterizing 24 disorders of the
brain, the resulting patterns can be combined to form a surprisingly
simple - but so far highly effective - approach to clinical
diagnosis. Moreover, these patterns offer a rare insight into
the disease process in that they show how the brain uses its parts
and connections to create distinct modules consistent with health
and disease. Since these hierarchical modules can be unique to
a single disorder or shared by several, one quickly discovers that
the complexity of even a simple disorder is extreme. By
unfolding disorders down to their smallest modules (mathematical
markers), one can reconstruct a family tree based on the 24
disorders. Such an exercise reveals intimate relationships of
one disease to another and begins to explain why these disorders can
be so difficult to diagnose. Such findings, of course, help to
unfold a new theory structure for biological complexity.
software package offers:
The Information Infrastructure.
digital library, including mathematical markers.
MRI database for the brain.
Updated programs, documents, and databases.
Updated theory structure for biological complexity.