the new software package. The Enterprise Biology Software Project
continues to accumulate a reservoir of published data, which, in
turn, are being run through an information infrastructure to
generate large amounts of new data and information. Since the
biology literature represents our data treasury, we can
advance our discipline by borrowing these data and investing them in new research ventures -
often with the expectation of a generous return. To
demonstrate the validity of such an investment strategy, the report
uses MRI data of a clinical paper to generate
detailed mathematical maps of the cerebral
Our return on investment includes a new way of diagnosing schizophrenia,
fresh insight into schizophrenia as a complex disease, and a simple,
method for leveraging our intellectual capital.
Mathematical mapping begins with the following argument.
If we assume that biological parts are designed by rules, then the
parts - by definition - express the rules. If true, then
we should be able to extract the rules directly from the parts.
The challenge, of course, becomes one of figuring out how to do it.
already know that the rules of order in biology exist as a
stoichiometry of parts, we can test our assumption by generating
triplets within and across hierarchical levels and then using them
to look for patterns in the data. By capturing spatial
patterns with n-dimensional graphics and rules with equations, we
begin to see the origins and products of biological order and
software package offers:
complete copy of the Information Infrastructure.
digital libraries for mathematical mapping based on triplets.
proposed theory structure for biological complexity.
Updates to programs and databases.