WELCOME

Welcome to the new software package.  The Enterprise Biology Software Project continues to accumulate a reservoir of published data, which, in turn, are being run through an information infrastructure to generate large amounts of new data and information.  Since the biology literature represents our data treasury, we can advance our discipline by borrowing these data and investing them in new research ventures - often with the expectation of a generous return.  To demonstrate the validity of such an investment strategy, the report uses MRI data of a clinical paper to generate detailed mathematical maps of the cerebral cortex.  Our return on investment includes a new way of diagnosing schizophrenia, fresh insight into schizophrenia as a complex disease, and a simple, but powerful method for leveraging our intellectual capital.   

Mathematical mapping begins with the following argument.  If we assume that biological parts are designed by rules, then the parts - by definition - express the rules.  If true, then we should be able to extract the rules directly from the parts.  The challenge, of course, becomes one of figuring out how to do it.

Since we already know that the rules of order in biology exist as a stoichiometry of parts, we can test our assumption by generating triplets within and across hierarchical levels and then using them to look for patterns in the data.  By capturing spatial patterns with n-dimensional graphics and rules with equations, we begin to see the origins and products of biological order and disorder. 

The software package offers:

• A progress report.

• A complete copy of the Information Infrastructure.

• An updated digital libraries for mathematical mapping based on triplets.

• Worked examples.

• A proposed theory structure for biological complexity.

• Updates to programs and databases.